Lasithi Plateau was first inhabited in the Neolithic age, since various caves of the surrounding settlements (such as the Trapeza Cave) were domiciles of Neolithic people, as shown by archeological research.
During the excavations led by Pendlebury in Lagos settlement, an ancient city from the middle Minoan period III was found. Furthermore, a settlement was discovered in Platis area by the Ancient Archaeological School in 1913 which had been inhabited from the first till the last late Minoan period.
There are no reliable sources for the following time periods. A deduction from the ruins of these periods is also impossible, since the destruction of Lasithi from the Venetians left no trace of life or ruins apart from some byzantine churches.
During the Second Crusade (1204 A.D.), Constantinople fell in the hands of the Crusaders and only a handful of provinces could be saved. The Crusaders then shared the vast empire between them.
Crete was given to Bonifatius, who was named King of Thessaloniki. The latter, sold Crete to the Venetians for a humiliating price in 1204 that in their turn seized and abused the fields of Crete.
Due to the above mentioned events, the Cretans started reacting and revolting from the first moment. Specifically, Lasithi Plateau (“a thorn in the heart of Venice”), due to its fertile grounds and its natural fortification potential, was the place where many revolts (such as the Hortatsos Revolt of 1273, the Kallergi brothers Revolt of 1363 etc.) started and the place where many rebels used as a hiding place.